The administration of drugs like aspirin, clopidogrel and cilostazol play an important. Insuficiencia hepatica leve nao altera a ligacao proteica. Learn about drug interactions between cilostazol oral and warfarin oral and use the rxlist drug interaction checker to check drug combinations. Longterm safety of cilostazol in patients with peripheral artery. In vitro metabolism and interaction of cilostazol with human hepatic cytochrome p450. O cilostazol e seus metabolitos ativos inibem a atividade da fosfodiesterase e suprimem a degradac.
Importance of taking cilostazol at least onehalf hour before or 2 hours after food. Trifusal y nitroaspirina y fosfodiesterasa dipiridamol y cilostazol. Cilostal antiagregante plaquetario laboratorio merck s. Safety and efficacy of cilostazol in the management of.
Cilostazol pletal is a phosphodiesterase type 3 inhibitor indicated for the improvement of walking distances in patients with intermittent claudication, who do not have rest pain and who do not. Cilostazol has demonstrated a smaller effect on bleeding time than that of other platelet inhibitors. Cilostazol does not appear to inhibit cyp3a4 see pharmacokinetic and pharmacodynamic drugdrug interactions, lovastatin. Por isso, recomendase sua administracao ao menos 30 minutos antes ou duas horas apos as refeicoes, minimizando os riscos dosedependentes.
Cilostazol is taken orally, and maximal plasma concentration of the drug is observed at 2. Cilostazol efectos secundarios, dosificacion, interacciones. Importance of informing patient that up to 12 weeks of cilostazol therapy may be required before symptomatic relief of intermittent claudication. If no improvement is seen after 3 months, stopping the medication is reasonable. Cilostazol controls the symptoms of intermittent claudication but does not cure it. Cilostazol is highly bound to plasma proteins, primarily albumin, and has a free fraction of up to 5% in patients with ic bramer et al 1999. In a study comparing the effects of ticlopidine, aspirin, and cilostazol on bleeding time in 10 healthy men age range 2739 years, bleeding time was significantly prolonged with aspirin and. Cilostazol, sold under the brand name pletal among others, is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease. Although you may notice improvements in 2 to 4 weeks, it may take up to 12 weeks before you notice the full benefit increased walking distance of cilostazol. Acetilsalicilico acido interactuando con cilostazol. In a study comparing the effects of ticlopidine, aspirin, and cilostazol on bleeding time in 10 healthy men age range 2739 years, bleeding time was significantly prolonged with aspirin and with ticlopidine administration. Pletal playtal cilostazol silostah zol tablets contraindication cilostazol and several of its metabolites are inhibitors of phosphodiesterase iii.